Simufilam (CAS 1224591-33-6)

Simufilam (CAS 1224591-33-6) is a small-molecule modulator of filamin A (FLNA), classified as a spirocyclic lactam compound. Its molecular formula is C₁₅H₂₁N₃O with a molecular weight of 259.35 g/mol. It is also known as PTI-125 and PTI-910.

Simufilam is reported to bind the C-terminal domain of filamin A, restoring its native conformation and attenuating aberrant protein–protein interactions associated with neuroinflammatory and neurodegenerative signaling cascades. This binding is proposed to reduce downstream dysregulation of α7 nicotinic acetylcholine receptors and toll-like receptor 4 complexes. The compound belongs to the 1,4,8-triazaspiro[4.5]decan-2-one chemotype, conferring conformational rigidity relevant to selective target engagement.

• Filamin A conformation and protein–protein interaction studies
• Neuroinflammatory pathway research in disease-model systems
• Chemical biology probe for FLNA–receptor complex profiling
• Structure-activity relationship studies within the spirocyclic lactam chemotype

Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.