1-(4-Azidophenyl)ethan-1-one (CAS 20062-24-2)

1-(4-Azidophenyl)ethan-1-one (CAS 20062-24-2) is an aromatic organic azide reagent used in click chemistry and photoaffinity labeling applications. Its molecular formula is C₈H₇N₃O with a molecular weight of 161.16 g/mol. It is also known as p-Azidoacetophenone and 4′-Azidoacetophenone.

The compound bears a para-azido group on an acetophenone scaffold, enabling participation in copper-catalyzed azide–alkyne cycloaddition (CuAAC) reactions with terminal alkynes to yield 1,2,3-triazole conjugates. The electron-withdrawing acetyl group modulates the electronic character of the aryl azide, which also undergoes photolytic nitrene insertion upon UV irradiation, making this compound a dual-mode bioconjugation handle.

• CuAAC-based bioconjugation and biomolecule labeling
• Photoaffinity probe construction for target identification studies
• Building block for synthesis of triazole-containing medicinal chemistry scaffolds
• Structure–activity relationship studies involving aryl azide pharmacophores

Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.