4-Azidobenzonitrile (CAS 18523-41-6)

4-Azidobenzonitrile (CAS 18523-41-6) is an aromatic azide reagent for copper-catalyzed azide–alkyne cycloaddition (CuAAC) and related click chemistry applications. Its molecular formula is C₇H₄N₄ with a molecular weight of 144.13 g/mol. It is also known as 4-cyanophenyl azide.

The compound bears a para-azido group on a benzonitrile scaffold, enabling [3+2] cycloaddition with terminal or internal alkynes under CuAAC conditions to yield 1,2,3-triazole conjugates. The electron-withdrawing nitrile substituent modulates the electronic character of the aromatic ring, influencing azide reactivity and the properties of the resulting triazole product. The compact, lipophilic aryl framework offers a low-molecular-weight handle for bioconjugation and probe assembly without introducing significant steric bulk.

• CuAAC-based bioconjugation and biomolecule labeling
• Construction of triazole-linked chemical probes for target profiling
• Building block for medicinal chemistry and structure–activity relationship studies
• Photoaffinity and azide-functionalized scaffold synthesis

Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.