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Click Chemistry
2-(4-Azidophenyl)acetic acid (CAS 62893-37-2)
Cat. No. SC10273
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 62893-37-2 |
| IUPAC Name | 2-(4-azidophenyl)acetic acid |
| Synonyms | 962-034-0; (4-azidophenyl)acetic acid; N3-PhAc-OH; 4-Azidobenzeneacetic acid; 4-azidophenylacetic acid |
| Molecular Weight | 177.16 g/mol |
| Molecular Formula | C8H7N3O2 |
| PubChem CID | 359422 |
| SMILES | C1=CC(=CC=C1CC(=O)O)N=[N+]=[N-] |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
2-(4-Azidophenyl)acetic acid (CAS 62893-37-2) is an aryl azide–functionalized acetic acid derivative used as a click chemistry building block and photoaffinity labeling reagent. Its molecular formula is C₈H₇N₃O₂ with a molecular weight of 177.16 g/mol. It is also known as 4-azidophenylacetic acid and N3-PhAc-OH.
The compound bears a para-azide group on a phenylacetic acid scaffold, enabling participation in copper-catalyzed azide–alkyne cycloaddition (CuAAC) reactions with terminal alkynes to yield stable 1,2,3-triazole linkages. The free carboxylic acid provides a convenient handle for amide bond formation or NHS ester activation, allowing dual-mode conjugation strategies in probe and linker assembly.
- Bioconjugation via CuAAC for antibody, peptide, and protein labeling
- Photoaffinity probe construction exploiting aryl azide photochemistry
- Synthesis of heterobifunctional linkers for PROTAC and ADC assembly
- Structure–activity relationship studies on azide-bearing phenylacetate scaffolds
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
