Click Chemistry

1-Azido-4-fluorobenzene (CAS 3296-02-4)

Cat. No. SC10270

⚠ This product is for research use only, not for human or veterinary use.

Chemical structure of 1-Azido-4-fluorobenzene

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Specifications

CAS Number 3296-02-4
IUPAC Name 1-azido-4-fluorobenzene
Synonyms 663-390-7; 4-fluorophenylazide; p-fluorophenyl azide
Molecular Weight 137.11 g/mol
Molecular Formula C6H4FN3
PubChem CID 10887974
SMILES C1=CC(=CC=C1N=[N+]=[N-])F
Purity >98%
Shipping Condition Shipped under ambient temperature as non-hazardous chemical.

Description

1-Azido-4-fluorobenzene (CAS 3296-02-4) is an aryl azide click chemistry reagent with molecular formula C₆H₄FN₃ and MW 137.11 g/mol. It is also known as 4-fluorophenyl azide and p-fluorophenyl azide.

This compound bears an aryl azide group para to a fluorine substituent on the benzene ring. In copper-catalyzed azide–alkyne cycloaddition (CuAAC), the azide reacts with terminal alkynes to form stable 1,2,3-triazole linkages under mild conditions. The para-fluoro group provides a handle for nucleophilic aromatic substitution, enabling further functionalization or serving as a metabolic/spectroscopic label in biological studies.

  • Bioconjugation and covalent labeling of alkyne-functionalized biomolecules via CuAAC
  • Synthesis of triazole-containing heterocyclic scaffolds for medicinal chemistry research
  • Photoaffinity labeling studies exploiting aryl azide photochemistry
  • Building block for construction of fluorine-tagged probes and tracers

Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.

Documentation

✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS

All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.

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