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Click Chemistry
1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane (CAS 59559-06-7)
Cat. No. SC10251
⚠ This product is for research use only, not for human or veterinary use.
![Chemical structure of 1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane](/structures/59559-06-7.png)
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Specifications
| CAS Number | 59559-06-7 |
| IUPAC Name | 1-azido-2-[2-(2-azidoethoxy)ethoxy]ethane |
| Synonyms | 111-043-0; Azido-PEG2-Azide; 1,2-Bis(2-azidoethoxy)ethane; Azide-PEG3-Azide; 1,8-DIAZIDO-3,6-DIOXAOCTANE; 1-Azido-2-(2-(2-azidoethoxy)ethoxy)ethane |
| Molecular Weight | 200.20 g/mol |
| Molecular Formula | C6H12N6O2 |
| PubChem CID | 10845705 |
| SMILES | C(COCCOCCN=[N+]=[N-])N=[N+]=[N-] |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane (CAS 59559-06-7) is a symmetric bis-azide PEG linker used in click chemistry and bioconjugation research. It is also known as Azido-PEG2-Azide and Azide-PEG3-Azide. Molecular formula C₆H₁₂N₆O₂; MW 200.20 g/mol.
This compound bears two terminal azide groups flanking a short diethylene glycol spacer. Both azides are reactive toward alkynes and cyclooctynes via copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted SPAAC, yielding stable 1,2,3-triazole linkages. The central PEG backbone imparts aqueous solubility and conformational flexibility to assembled conjugates.
- Bifunctional crosslinking of two alkyne- or cyclooctyne-bearing biomolecules
- Construction of PEG-spaced dual-probe or dual-payload conjugates for chemical biology studies
- Building block for PROTAC, ADC, or other heterobifunctional linker assembly
- Structure–activity relationship studies requiring symmetric azide-terminated spacers
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
