APIs & Intermediates
X-396 (CAS 1365267-27-1)
Cat. No. SC10178
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1365267-27-1 |
| IUPAC Name | 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide |
| Synonyms | X-376; 3-Pyridazinecarboxamide, 6-amino-5-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((4-methyl-1-piperazinyl)carbonyl)phenyl)- |
| Molecular Weight | 547.40 g/mol |
| Molecular Formula | C25H25Cl2FN6O3 |
| PubChem CID | 56960447 |
| SMILES | CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
X-396 (CAS 1365267-27-1) is a selective anaplastic lymphoma kinase (ALK) inhibitor with molecular formula C₂₅H₂₅Cl₂FN₆O₃ and MW 547.40 g/mol. It is also known as X-376.
X-396 is reported to act as an ATP-competitive inhibitor of ALK, a receptor tyrosine kinase implicated in oncogenic signaling driven by chromosomal rearrangements such as EML4-ALK fusions. The compound selectively binds the ALK kinase domain and is reported to suppress downstream proliferative and survival pathways, including JAK-STAT and PI3K/AKT signaling, in ALK-positive cellular models.
- ALK kinase biochemical and cellular inhibition studies
- Disease-model research in ALK-rearranged malignancies
- Structure-activity relationship studies within the aminopyridazine chemotype
- Resistance mechanism profiling against ALK inhibitor scaffolds
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
