APIs & Intermediates
A-1210477 (CAS 1668553-26-1)
Cat. No. SC10134
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1668553-26-1 |
| IUPAC Name | 7-[5-[[4-[4-(dimethylsulfamoyl)piperazin-1-yl]phenoxy]methyl]-1,3-dimethylpyrazol-4-yl]-1-(2-morpholin-4-ylethyl)-3-(3-naphthalen-1-yloxypropyl)indole-2-carboxylic acid |
| Synonyms | Abbvie Mcl-1 Inhibitor; mc1 Inhibitor; 7-(5-((4-(4-(N,N-Dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid |
| Molecular Weight | 850.00 g/mol |
| Molecular Formula | C46H55N7O7S |
| PubChem CID | 66575373 |
| SMILES | CC1=NN(C(=C1C2=CC=CC3=C2N(C(=C3CCCOC4=CC=CC5=CC=CC=C54)C(=O)O)CCN6CCOCC6)COC7=CC=C(C=C7)N8CCN(CC8)S(=O)(=O)N(C)C)C |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
A-1210477 (CAS 1668553-26-1) is a selective MCL-1 inhibitor belonging to the indole-2-carboxylic acid chemotype. With a molecular formula of C₄₆H₅₅N₇O₇S and a molecular weight of 850.00 g/mol, it is also known as AbbVie MCL-1 Inhibitor.
A-1210477 is reported to bind directly to the BH3-binding groove of MCL-1 (myeloid cell leukemia 1), a pro-survival BCL-2 family protein, thereby displacing pro-apoptotic BH3-only proteins and restoring apoptotic signaling. It exhibits selectivity for MCL-1 over other BCL-2 family members, including BCL-2 and BCL-XL, making it a useful tool for dissecting MCL-1-specific contributions to apoptotic regulation.
- MCL-1 target engagement and BH3 displacement assays
- Apoptosis pathway research in hematologic and solid tumor cell models
- Structure-activity relationship studies within the BH3-mimetic chemotype
- Chemical biology probe for BCL-2 family protein profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
