APIs & Intermediates
VH298 (CAS 2097381-85-4)
Cat. No. SC10068
⚠ This product is for research use only, not for human or veterinary use.
Request a Quote
We typically respond within 1 business day.
Specifications
| CAS Number | 2097381-85-4 |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Synonyms | (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Molecular Weight | 523.60 g/mol |
| Molecular Formula | C27H33N5O4S |
| PubChem CID | 122199236 |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
VH298 (CAS 2097381-85-4) is a potent VHL E3 ligase ligand and cell-permeable hypoxia-inducible factor (HIF) stabilizer. Its molecular formula is C₂₇H₃₃N₅O₄S with a molecular weight of 523.60 g/mol. The compound is also known as VH298 in the targeted protein degradation literature and serves as a validated VHL-binding warhead in PROTAC design.
VH298 is reported to bind the von Hippel–Lindau (VHL) protein with high affinity, competitively blocking the interaction between VHL and hydroxyproline-containing HIF-1α peptides. By occupying the VHL substrate-binding site, it stabilizes HIF-α subunits and activates downstream hypoxia-response pathways in normoxic conditions. The compound incorporates a hydroxyproline-containing pyrrolidine scaffold characteristic of optimized VHL ligands.
- VHL–HIF protein–protein interaction studies
- Chemical biology probe for hypoxia-pathway modulation
- PROTAC and targeted protein degradation tool compound
- Structure-activity relationship studies of VHL ligands
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
