APIs & Intermediates
Savolitinib (CAS 1313725-88-0)
Cat. No. SC10025
⚠ This product is for research use only, not for human or veterinary use.
Request a Quote
We typically respond within 1 business day.
Specifications
| CAS Number | 1313725-88-0 |
| IUPAC Name | 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine |
| Synonyms | Volitinib; savolitinibum; HMPL-504; AZD-6094 |
| Molecular Weight | 345.40 g/mol |
| Molecular Formula | C17H15N9 |
| PubChem CID | 68289010 |
| SMILES | CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
Savolitinib (CAS 1313725-88-0) is a selective, ATP-competitive MET kinase inhibitor with molecular formula C₁₇H₁₅N₉ and MW 345.40 g/mol. It is also known as Volitinib, HMPL-504, and AZD-6094.
Savolitinib is reported to selectively inhibit the MET receptor tyrosine kinase by competing with ATP at the catalytic binding site. This inhibition suppresses downstream signaling through the PI3K/AKT and RAS/MAPK pathways, which are implicated in cellular proliferation, survival, and invasive growth driven by MET dysregulation, including amplification, mutation, and exon 14 skipping alterations.
- Selective MET kinase inhibition and target engagement studies
- MET-driven oncology disease-model research
- Structure-activity relationship studies within the MET inhibitor chemotype
- Chemical biology probe for MET pathway profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
