APIs & Intermediates
SAR-20347 (CAS 1450881-55-6)
Cat. No. SC10071
⚠ This product is for research use only, not for human or veterinary use.
Request a Quote
We typically respond within 1 business day.
Specifications
| CAS Number | 1450881-55-6 |
| IUPAC Name | 2-(2-chloro-6-fluorophenyl)-5-[4-(morpholine-4-carbonyl)anilino]-1,3-oxazole-4-carboxamide |
| Synonyms | GTPL9803; C21H18ClFN4O4; 2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide |
| Molecular Weight | 444.80 g/mol |
| Molecular Formula | C21H18ClFN4O4 |
| PubChem CID | 71727668 |
| SMILES | C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
SAR-20347 (CAS 1450881-55-6) is a selective TYK2 inhibitor belonging to the oxazole-carboxamide chemotype. Its molecular formula is C₂₁H₁₈ClFN₄O₄ with a molecular weight of 444.80 g/mol.
SAR-20347 is reported to inhibit tyrosine kinase 2 (TYK2), a member of the JAK family of non-receptor tyrosine kinases involved in cytokine signaling through the JAK-STAT pathway. It selectively targets the TYK2 pseudokinase (JH2) regulatory domain, suppressing downstream signaling mediated by IL-12, IL-23, and type I interferons. This allosteric mechanism distinguishes it from pan-JAK inhibitors and has made it a subject of interest in autoimmune and inflammatory disease research.
- Target enzymology and selectivity profiling of TYK2 and related JAK family members
- Disease-model research in autoimmune and inflammatory conditions
- Chemical biology probe for JAK-STAT pathway studies
- Structure-activity relationship studies within the oxazole-carboxamide scaffold
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
