APIs & Intermediates
RS 102895 hydrochloride (CAS 300815-41-2)
Cat. No. SC10147
⚠ This product is for research use only, not for human or veterinary use.
Request a Quote
We typically respond within 1 business day.
Specifications
| CAS Number | 300815-41-2 |
| IUPAC Name | 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one;hydrochloride |
| Synonyms | abaucin; hydrochloride; RS 102895; 1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride |
| Molecular Weight | 426.90 g/mol |
| Molecular Formula | C21H22ClF3N2O2 |
| PubChem CID | 16759153 |
| SMILES | C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
RS 102895 hydrochloride (CAS 300815-41-2) is the hydrochloride salt form of RS 102895, a selective CCR2 (CC chemokine receptor 2) antagonist. Its molecular formula is C₂₁H₂₂ClF₃N₂O₂ with a molecular weight of 426.90 g/mol. It is also known as RS-102895.
RS 102895 is reported to act as a potent, selective antagonist of CCR2, a G protein-coupled receptor that mediates monocyte and macrophage recruitment in response to CCL2 (MCP-1) signaling. The compound binds CCR2 and is reported to block downstream chemokine-driven inflammatory responses without significant activity at related chemokine receptors such as CCR1 or CCR5.
- CCR2 receptor pharmacology and binding studies
- Inflammatory pathway and monocyte recruitment research
- Disease-model research in metabolic and neuroinflammatory contexts
- Structure-activity relationship studies within the spiro-oxazinone chemotype
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
