APIs & Intermediates
NB-360 (CAS 1262857-73-7)
Cat. No. SC10216
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1262857-73-7 |
| IUPAC Name | N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide |
| Synonyms | NB-360 HCl; N-[3-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide |
| Molecular Weight | 449.40 g/mol |
| Molecular Formula | C21H19F4N5O2 |
| PubChem CID | 66665322 |
| SMILES | CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)C3(COC(C(=N3)N)(C)C(F)(F)F)C)C#N |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
NB-360 HCl (CAS 1262857-73-7) is the hydrochloride salt form of NB-360, a potent and selective β-secretase 1 (BACE1) inhibitor. Its molecular formula is C₂₁H₁₉F₄N₅O₂ (free base; HCl salt MW: 449.40 g/mol). It is also known as NB-360 HCl.
NB-360 is reported to inhibit BACE1, an aspartyl protease responsible for the rate-limiting cleavage of amyloid precursor protein (APP) to generate amyloidogenic Aβ peptides. The compound acts as a non-covalent active-site inhibitor, selectively engaging the catalytic aspartate dyad of BACE1 and reducing Aβ production in cellular and in vivo models. Its oxazine-based scaffold confers favorable CNS penetration properties.
- BACE1 target engagement and enzyme kinetics studies
- Amyloid pathway research in neurodegeneration disease models
- Structure-activity relationship studies on oxazine-class BACE inhibitors
- Chemical biology probe for aspartyl protease selectivity profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
