APIs & Intermediates
Labuxtinib (CAS 1426449-01-5)
Cat. No. SC10212
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1426449-01-5 |
| IUPAC Name | N-[5-[5-[(1R,2S)-2-fluorocyclopropyl]-1,2,4-oxadiazol-3-yl]-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide |
| Synonyms | THB335; N-(5-(5-((1R,2S)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide |
| Molecular Weight | 377.40 g/mol |
| Molecular Formula | C20H16FN5O2 |
| PubChem CID | 71280305 |
| SMILES | CC1=C(C=C(C=C1)C2=NOC(=N2)C3CC3F)NC(=O)C4=CN=C5N4C=CC=C5 |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
Labuxtinib (CAS 1426449-01-5) is a selective ITK (interleukin-2-inducible T-cell kinase) inhibitor with molecular formula C₂₀H₁₆FN₅O₂ and MW 377.40 g/mol. It is also known as THB335. The compound features an imidazo[1,2-a]pyridine-3-carboxamide core linked to a 1,2,4-oxadiazole bearing a (1R,2S)-2-fluorocyclopropyl substituent.
Labuxtinib is reported to selectively inhibit ITK, a non-receptor tyrosine kinase of the TEC family that plays a central role in T-cell receptor signaling and downstream activation of PLCγ1. By blocking ITK activity, the compound modulates Th2-skewed immune responses and cytokine production, making it a useful tool for dissecting T-cell–mediated inflammatory pathways.
- ITK target engagement and T-cell signaling pathway studies
- Disease-model research in T-cell–driven inflammatory and allergic conditions
- Structure-activity relationship studies within the TEC-family kinase inhibitor chemotype
- Chemical biology probe for ITK selectivity profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
