APIs & Intermediates
KSQ-4279 (CAS 2446480-97-1)
Cat. No. SC10155
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 2446480-97-1 |
| IUPAC Name | 6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine |
| Synonyms | USP1-IN-1; example 143 [WO2020132269A1]; example 143 (WO2020132269A1); 1H-Pyrazolo(3,4-d)pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-((4-(1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)methyl)- |
| Molecular Weight | 534.50 g/mol |
| Molecular Formula | C27H25F3N8O |
| PubChem CID | 150782011 |
| SMILES | CC(C)N1C=C(N=C1C2=CC=C(C=C2)CN3C4=NC(=NC=C4C=N3)C5=C(N=CN=C5OC)C6CC6)C(F)(F)F |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
KSQ-4279 (CAS 2446480-97-1) is a selective USP1 (ubiquitin-specific protease 1) inhibitor with molecular formula C₂₇H₂₅F₃N₈O and molecular weight 534.50 g/mol. It is also known as USP1-IN-1.
USP1 is a deubiquitinase that removes monoubiquitin from PCNA and FANCD2, thereby regulating DNA damage tolerance and the Fanconi anemia pathway. KSQ-4279 is reported to inhibit USP1 with high potency and selectivity, disrupting these deubiquitination events and impairing DNA repair signaling in cancer cell models. Its pyrazolo[3,4-d]pyrimidine core engages the catalytic site of USP1, while the trifluoromethylimidazole and cyclopropylmethoxypyrimidine substituents contribute to binding affinity and selectivity.
- USP1 target enzymology and deubiquitinase pathway studies
- DNA damage response and Fanconi anemia pathway research
- Chemical biology probe for ubiquitin signaling profiling
- Structure-activity relationship studies within the pyrazolopyrimidine chemotype
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
