APIs & Intermediates
GSK-2636771 (CAS 1372540-25-4)
Cat. No. SC10169
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1372540-25-4 |
| IUPAC Name | 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid |
| Synonyms | 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-morpholin-4-ylbenzimidazole-4-carboxylic acid |
| Molecular Weight | 433.40 g/mol |
| Molecular Formula | C22H22F3N3O3 |
| PubChem CID | 56949517 |
| SMILES | CC1=C(C=CC=C1C(F)(F)F)CN2C(=NC3=C(C=C(C=C32)N4CCOCC4)C(=O)O)C |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
GSK-2636771 (CAS 1372540-25-4) is a selective PI3Kβ (phosphoinositide 3-kinase beta) inhibitor with molecular formula C₂₂H₂₂F₃N₃O₃ and molecular weight 433.40 g/mol. The compound is a benzimidazole-4-carboxylic acid derivative bearing a 2-methyl-3-(trifluoromethyl)benzyl substituent and a morpholine ring at the 6-position.
GSK-2636771 is reported to selectively inhibit the PI3Kβ isoform in an ATP-competitive manner, with substantially reduced activity against PI3Kα, PI3Kγ, and PI3Kδ. PI3Kβ plays a central role in PTEN-deficient tumor cell survival and AKT/mTOR pathway signaling, making isoform-selective inhibition of this enzyme a subject of considerable research interest in oncology.
- PI3Kβ isoform selectivity and kinase inhibition profiling studies
- PTEN-loss tumor model research and AKT pathway mechanistic studies
- Structure-activity relationship studies within the benzimidazole PI3K inhibitor chemotype
- Chemical biology probe for PI3K signaling network characterization
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
