APIs & Intermediates
BAY-1082439 (CAS 1375469-38-7)
Cat. No. SC10079
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1375469-38-7 |
| IUPAC Name | N-[8-[(2R)-2-hydroxy-3-morpholin-4-ylpropoxy]-7-methoxy-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]-2-methylpyridine-3-carboxamide |
| Synonyms | BAY-1082439 [WHO-SDG]; (R)-Nedisertib (M3814; RMSC2490484A); (R)-N-(8-(2-Hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide |
| Molecular Weight | 494.50 g/mol |
| Molecular Formula | C25H30N6O5 |
| PubChem CID | 135905473 |
| SMILES | CC1=C(C=CC=N1)C(=O)N=C2N=C3C(=C4N2CCN4)C=CC(=C3OC)OCC(CN5CCOCC5)O |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
BAY-1082439 (CAS 1375469-38-7) is a selective DNA-dependent protein kinase (DNA-PK) inhibitor with molecular formula C₂₅H₃₀N₆O₅ and MW 494.50 g/mol. It is also known as M3814 and nedisertib.
BAY-1082439 is reported to act as a potent, selective inhibitor of DNA-PK, a serine/threonine kinase central to the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. By competitively occupying the ATP-binding site of DNA-PK, the compound is reported to impair NHEJ-mediated repair, thereby sensitizing cells to DNA-damaging insults such as ionizing radiation and certain genotoxic agents.
- DNA-PK target engagement and NHEJ pathway studies
- Radiosensitization and DNA damage response research
- Structure-activity relationship studies within the imidazo[1,2-c]quinazoline chemotype
- Chemical biology probe for DNA repair pathway profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
