APIs & Intermediates
AZD 3147 (CAS 1101810-02-9)
Cat. No. SC10016
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1101810-02-9 |
| IUPAC Name | 1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)thiourea |
| Synonyms | 1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)thiourea |
| Molecular Weight | 517.70 g/mol |
| Molecular Formula | C24H31N5O4S2 |
| PubChem CID | 25168990 |
| SMILES | CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C4CC4)C5=CC=C(C=C5)NC(=S)NCCO |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
AZD 3147 (CAS 1101810-02-9) is a dual mTORC1/mTORC2 inhibitor belonging to the pyrimidine-based kinase inhibitor chemotype. Its molecular formula is C₂₄H₃₁N₅O₄S₂ with a molecular weight of 517.70 g/mol.
AZD 3147 is reported to selectively inhibit both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) through ATP-competitive binding at the mTOR kinase domain. By suppressing both complexes simultaneously, it is reported to block downstream signaling through S6K1/4E-BP1 and AKT(Ser473), offering more complete pathway inhibition than rapalog-class allosteric inhibitors. This dual blockade is relevant to PI3K/AKT/mTOR pathway research in oncology and metabolic disease contexts.
- Target enzymology and signaling pathway studies in the mTOR/PI3K axis
- Disease-model research in oncology and metabolic disorders
- Chemical biology probe for mTORC1/mTORC2 selectivity profiling
- Structure-activity relationship studies within the pyrimidine sulfonylcyclopropyl chemotype
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
