APIs & Intermediates
Ravoxertinib (CAS 1453848-26-4)
Cat. No. SC10133
⚠ This product is for research use only, not for human or veterinary use.
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Specifications
| CAS Number | 1453848-26-4 |
| IUPAC Name | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one |
| Synonyms | GDC-0994; RG-7842; 1-[(1S)-1-(4-CHLORO-3-FLUOROPHENYL)-2-HYDROXYETHYL]-4-{2-[(2-METHYLPYRAZOL-3-YL)AMINO]PYRIMIDIN-4-YL}PYRIDIN-2-ONE |
| Molecular Weight | 440.90 g/mol |
| Molecular Formula | C21H18ClFN6O2 |
| PubChem CID | 71727581 |
| SMILES | CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(C=C4)Cl)F |
| Purity | >98% |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
Description
Ravoxertinib (CAS 1453848-26-4) is a selective ERK1/2 inhibitor with molecular formula C₂₁H₁₈ClFN₆O₂ and molecular weight 440.90 g/mol. It is also known as GDC-0994 and RG-7842.
Ravoxertinib is reported to act as a potent, ATP-competitive inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2), the terminal effector kinases of the RAS–RAF–MEK–ERK mitogen-activated protein kinase (MAPK) cascade. By occupying the ATP-binding pocket, it is reported to suppress ERK1/2 catalytic activity and downstream phosphorylation of substrates involved in cell proliferation and survival. Its selectivity profile makes it a useful tool for dissecting ERK-dependent signaling in MAPK-dysregulated cellular contexts.
- ERK1/2 target engagement and MAPK pathway studies
- Disease-model research in RAS/RAF-mutant tumor biology
- Structure-activity relationship studies on pyridinone-pyrimidine ERK inhibitor scaffolds
- Chemical biology probe for ERK substrate phosphorylation profiling
Each batch is analyzed by HPLC and ¹H NMR, with a Certificate of Analysis provided on shipment. Available from milligram to kilogram scale, with flexible packaging to meet R&D and scale-up requirements.
Documentation
✓ Certificate of Analysis (CoA) ✓ ¹H NMR Spectrum ✓ HPLC Chromatogram ✓ LC-MS (on request) ✓ MSDS / SDS
All analytical documentation is provided free of charge with every order. Raw spectral data files (NMR, HPLC, LC-MS) are also available on request — just mention it in your enquiry.
